Chromomycin a2
WebThe antitumor antibiotics mithramycin A and chromomycin A3 bind reversibly to the minor groove of G/C-rich regions in DNA in the presence of dications such as Mg2+, and their antiproliferative activity has been associated with their ability to block the binding of certain transcription factors to gene promoters. Despite their biological activity, their use as … WebChromomycin A 2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. 1, 2 Chromomycin A 2 inhibits the …
Chromomycin a2
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WebChromomycin Ag (1) Chromomycin A, is composed of the chromophorc, chromomycinone1'"1* (abbreviated to CHR) and the four chromoses. A, B, C and D. … WebExposure to chromomycin A2 induced accumulation of cells in G0/G1 phase of the cell cycle, with consequent reduction of S and G2/M and unbalanced expression of cyclins, and the appearance of acidic vacuolar organelles in treated cells are suggestive of the induction of autophagy promoted by chromomycins. 19 PDF References
http://www.fluoroprobe.com/archives/tag/citral WebChromomycin A3 (CMA3) or Toyomycin is an anthraquinone antibiotic glycoside produced by the fermentation of a certain strain of Streptomyces griseus (No. 7). [1] Fluorescence …
WebDec 3, 2024 · In this study, using multiple phenotypic analyses, we found that one of the top natural product hits, chromomycin A2 (CMA2), potently inhibited insulin secretion by at least three potential mechanisms: disruption of Wnt signaling, interference of β cell gene expression, and partial suppression of Ca 2+ influx. WebG-C specific intercalating agents [actinomycin D (AMD) and chromomycin A3 at 1 microM] also prevented ER disappearance; ethidium bromide (EB) and quinacrine were ineffective. AMD and CHX operated immediately after their addition to the medium indicating an inhibitory action on the synthesis of an RNA and/or a peptide with high turnover rate ...
WebThe principal constituent, chromomycin A3 (l) is commercially available, while chromomycin A2 (2J and chromomycin A4 (3) are the major by- products isolated …
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